5-Amino 1MQ (5-amino-1-methylquinolinium) is a synthetic small-molecule research compound studied for its effects on metabolism through inhibition of the enzyme Nicotinamide N-methyltransferase (NNMT).

1. Identification

Common name: 5-Amino 1MQ

Full chemical name: 5-amino-1-methylquinolinium

Chemical class: Quinolinium-based small molecule

Type: Experimental metabolic research compound

Target enzyme: NNMT (Nicotinamide N-methyltransferase)

2. Chemical Information

Molecular formula (cation): C₁₀H₁₁N₂⁺

Typical salt form: iodide or chloride

Molecular weight:

• ~159 g/mol (free form)

• ~280–290 g/mol (iodide salt, common research form)

Structure: Aromatic quinoline ring with:

• A permanent positive nitrogen (N-methyl group)

• An amino group at position 5

3. Physical Properties

Appearance: Off-white to light yellow powder

Solubility: Highly soluble in water

Polarity: High (due to permanent positive charge)

Stability: Chemically stable under normal storage conditions

Lipophilicity: Moderate (balances aromatic ring + charged nitrogen)

4. Mechanism of Action (Simple Overview)

5-Amino 1MQ works by:

• Blocking NNMT enzyme activity

• Increasing availability of nicotinamide (vitamin B3 derivative)

• Supporting NAD⁺ metabolism

This may lead to:

• Improved cellular energy production

• Altered fat metabolism

• Increased mitochondrial efficiency (preclinical evidence)

5. Primary Research Areas

5-Amino 1MQ is mainly studied in:

• Obesity and fat metabolism research

• NAD⁺ and cellular energy pathways

• Insulin sensitivity and glucose metabolism

• Mitochondrial function

• Metabolic syndrome models

6. Observed Effects (Preclinical Data Only)

In animal and laboratory studies:

• Reduced body fat accumulation

• Smaller adipocyte (fat cell) size
• Increased energy expenditure

• Improved metabolic markers

• Changes in NAD⁺-related pathways

These findings are not confirmed in large human clinical trials.

7. Safety and Regulatory Status

Human approval: None

Clinical use: Not approved as a medication

Evidence level: Preclinical (cell + animal studies only)

Long-term safety: Not established

8. Key Takeaway

5-Amino 1MQ is a research-only metabolic compound designed to inhibit NNMT and influence NAD⁺-related energy pathways. It is mainly studied for potential effects on fat metabolism and cellular energy regulation, but it remains experimental with no confirmed human therapeutic use.