Acetyl Hexapeptide-1 is a synthetic cosmetic peptide (hexapeptide = 6 amino acids) used in skincare products designed to improve skin tone, brightness, and overall appearance, especially in anti-aging and anti-pigmentation formulations.
1. Name & Classification
- INCI name: Acetyl Hexapeptide-1
- Type: Synthetic peptide
- Category: Biomimetic / signal peptide
- Cosmetic role: Skin tone–regulating active ingredient
- Common trade name: Often marketed as Melitane™ in cosmetic blends
2. Origin
- Developed through cosmetic biotechnology and peptide engineering
- Inspired by natural peptides involved in skin pigmentation regulation
- Designed to mimic or influence melanocyte signaling pathways
3. Chemical Structure (basic)
- Length: 6 amino acids (hexapeptide)
- Modification: N-terminal acetylation (Ac- group)
- Molecular weight: ~700–900 Da
- Structure type: Linear peptide (non-cyclic)
4. Physical Properties
- Appearance: White to off-white powder (pure form)
- Solubility: Highly soluble in water
- Stability: Moderate (sensitive to heat, pH extremes, and enzymes)
- Storage: Cool, dry conditions; often refrigerated in bulk form
5. Main Functions (simple overview)
Acetyl Hexapeptide-1 is mainly used to:
- Improve skin brightness and radiance
- Support even skin tone
- Reduce appearance of dark spots and pigmentation irregularities
- Help manage photoaging-related skin changes
6. How it works (basic idea)
It works by:
- Modulating melanocyte activity (pigment-producing cells)
- Influencing signaling pathways related to melanin production
- Helping balance skin’s response to UV and oxidative stress
7. Applications in skincare
Commonly found in:
- Brightening serums
- Anti-dark spot creams
- Anti-aging skincare products
- Eye-area radiance treatments
- Multi-peptide cosmetic blends
8. Safety profile
- Generally considered safe for topical cosmetic use
- Low irritation potential
- No known systemic toxicity at cosmetic concentrations
- Not intended for injection or medical use
9. Key takeaway
Acetyl Hexapeptide-1 is a cosmetic signal peptide designed to improve skin tone and brightness by influencing pigmentation-related cellular signaling, with mild anti-aging support and good safety in topical skincare.